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R-3750 in Patients With Crohn's Disease

Name: R-3750 in Patients With Crohn's Disease — clinical trial record (NCT07791888)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusNot Yet Recruiting

PhasePhase 1

SponsorRise Therapeutics LLC

Started2026-11-01

View on ClinicalTrials.gov ↗

This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, clinical activity, and pharmacodynamic effects of R-3750 in adults with active Crohn's disease. Approximately 40 participants will be randomized 1:1 to receive R-3750 or matching placebo orally once daily for 12 weeks. Participants will be followed for safety, clinical response, and durability of response through approximately Day 168. Assessments will include adverse events, Crohn's disease activity, endoscopic response, patient-reported outcomes, inflammatory biomarkers, microbiome composition, and pharmacodynamic measures.

Trial Details

NCT Number	NCT07791888
Lead Sponsor	Rise Therapeutics LLC
Conditions	Crohn Disease (CD)
Enrollment	40 participants
Start Date	2026-11-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-28