Skip to content
DataLookout
Start free
Menu

NCT07788755

NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia

StatusNot Yet Recruiting
PhaseNot applicable
Primary completion (estimated)
Track this trial

Free. We email you which fields changed when ClinicalTrials.gov updates this record.

Record History

All 3 versions: 3 with changes below. See every version on ClinicalTrials.gov ↗

  1. Start date pushed from Nov 2, 2026 to Nov 16, 2026
  2. Start date: Oct 1, 2026 to Nov 2, 2026
    • Primary endpoints: details revised at 2 of 3 entries
    • Eligibility criteria expanded, about 35 words
    • Secondary endpoints: details revised at 5 of 5 entries
  3. Study First Submitted
  • Notable: the plan changed
  • Minor: routine updates

Endpoints

Primary

Change in DPX Task Performance
Timeframe: Baseline to post-training follow-up, up to 7 months; or baseline to post-training follow-up, up to 42 months for participants completing the optional extended baseline component
Number of participants with pre/post EEG data
Timeframe: Baseline to post-training follow-up, up to 7 months; or baseline to post-training follow-up, up to 42 months for participants completing the optional extended baseline component
Number of participants with pre/post Magnetic Resonance Spectroscopy data
Timeframe: Baseline to post-training follow-up, up to 7 months; or baseline to post-training follow-up, up to 42 months for participants completing the optional extended baseline component

Secondary (5)

Change in Brief Psychiatric Rating Scale Score
Change in Positive Symptom Scores
Change in Negative Symptom Scores
Change in World Health Organization Disability Assessment Schedule Score
Change in Global Functioning Role Scale Score

Arms and interventions

Perceptual Discrimination TrainingExperimental

Participants randomized to this arm will complete computerized perceptual discrimination training. The training involves Gabor patch and other visual stimulus discrimination exercises designed to improve signal-to-noise resolution and attentional control. Participants will complete approximately 10 hours of training over 2 to 6 weeks.

Cognitive Control TrainingExperimental

Participants randomized to this arm will complete computerized cognitive control training. The training involves exercises focused on maintaining cognitive context in working memory during response selection. Participants will complete approximately 10 hours of training over 2 to 6 weeks.

Devices: Perceptual Discrimination Training, Cognitive Control Training

Sites

1 site in 1 country

  • Center for Magnetic Resonance Research, University of MinnesotaMinneapolis, Minnesota, United States