A Prospective Multicenter Real-World Registry of Quantitative Flow Ratio-Guided Coronary REvascularization and QuAlity evaLuation

This prospective, multicenter observational registry aims to establish a QFR-based quality control standard system for coronary revascularization in patients with coronary artery disease. The study will enroll over 10,000 patients with visually estimated at least one main branch coronary stenosis ≥50% from more than 50 centers across China (covering provincial, municipal, and county-level hospitals). Coronary angiographic images and intracoronary imaging (if available) will be collected and retrospectively analyzed by an independent core laboratory. The primary endpoint is QFR acquisition accessibility, defined as the mean of QFR usage proportion across centers.

NCT Number	NCT07766434
Lead Sponsor	China National Center for Cardiovascular Diseases Collaborators: Guangdong Provincial People's Hospital, First Affiliated Hospital Xi'an Jiaotong University, Sir Run Run Shaw Hospital, Fuwai Huazhong Cardiovascular Hospital, Fuwai Yunnan Cardiovascular Hospital, Second Hospital of Jilin University
Conditions	Coronary Artery Disease
Enrollment	10,000 participants
Start Date	2026-08
Primary Completion	2028-07 (estimated)
Study Completion	2029-07 (estimated)
Updated on ClinicalTrials.gov	2026-08-14