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Study of Resmetirom in Children and Adolescents With MASH

Name: Study of Resmetirom in Children and Adolescents With MASH — clinical trial record (NCT07763015)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 2

SponsorMadrigal Pharmaceuticals, Inc.

Started2026-08-01

View on ClinicalTrials.gov ↗

Amendment history

2026-09-10

Study Status, Contacts/Locations v1

Recruitment opened

Start dateestimated 2026-08→confirmed 2026-08-01

Study sitesdetails revised at 1 of 1 site

2026-08-10

Original filing

Madrigal Pharmaceuticals, Inc.

9 trials monitored

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NASH / MASH

645 trials monitored

See 22 trials at risk

This study will evaluate the safety, pharmacokinetics (how the body absorbs, distributes, metabolizes, and eliminates the drug), and pharmacodynamics (how the drug affects the body) of resmetirom in children and adolescents with metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. Participants will receive oral resmetirom once daily for approximately 14 days at one of several dose levels. The information from this study will help determine appropriate dosing and further evaluate the safety and biological effects of resmetirom in pediatric participants with MASH.

Trial Details

NCT Number	NCT07763015
Lead Sponsor	Madrigal Pharmaceuticals, Inc.
Conditions	MASH, MASH - Metabolic Dysfunction-Associated Steatohepatitis
Enrollment	61 participants
Start Date	2026-08-01
Primary Completion	2029-07 (estimated)
Study Completion	2029-07 (estimated)
Updated on ClinicalTrials.gov	2026-09-11