CAPITAL OFFLOAD-SHOCK

CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital death when compared to the current standard of care. The current standard of care is to wait until renal replacement therapy is clinically necessary.

NCT Number	NCT07756801
Lead Sponsor	Ottawa Heart Institute Research Corporation
Conditions	Hypervolemia, Cardiogenic Shock, Renal Replacement Therapy
Enrollment	456 participants
Start Date	2026-09-01
Primary Completion	2027-09 (estimated)
Study Completion	2031-09 (estimated)
Updated on ClinicalTrials.gov	2026-08-11