Clinical Trial

Adaptive Phase 1/2 Study of Dual-Target CAR-NK Cells in Relapsed/Refractory Small Cell Lung Cancer (SCLC)

Recruiting Phase 1/2
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Summary
This example study is an open-label, multi-center, adaptive Phase 1/2 trial evaluating the safety, feasibility, and preliminary antitumor activity of allogeneic dual-target CAR-NK cell products in adults with relapsed or refractory small cell lung cancer (SCLC). Three candidate dual-target constructs (DLL3/CD56, DLL3/GD2, and CD56/GD2) will be assessed during dose escalation; a pre-specified interim assessment will select the most suitable construct to proceed into an expansion cohort at the recommended Phase 2 dose (RP2D).
Trial Details
NCT Number NCT07744256
Lead Sponsor Beijing Biotech
Conditions Small Cell Lung Cancer (SCLC), Relapsed/Refractory SCLC, Extensive-stage SCLC
Enrollment 60 participants
Start Date 2026-03-02
Primary Completion 2027-02-14 (estimated)
Study Completion 2028-03-17 (estimated)
Updated on ClinicalTrials.gov 2026-08-04