Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care

Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. A major barrier to improving ROP outcomes is the lack of easy access and low stress means to obtain objective measures of ROP disease severity across the retina in these infants. The long-term goal of this program is to provide information which will improve preterm infant health and vision via objective bedside imaging and analysis that characterizes retina-wide ROP level of disease, its response to treatment and development, and to rapidly translate this for better early intervention and improved future vision care.

NCT Number	NCT07738874
Lead Sponsor	Duke University Collaborators: University of Pennsylvania, National Eye Institute (NEI)
Conditions	Retinopathy of Prematurity (ROP)
Enrollment	175 participants
Start Date	2026-07-01
Primary Completion	2031-06-30 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-31