RISE: Reducing Cancer and HIV Stigma Through Empowerment

This multilevel randomized behavioral study evaluates participant- and provider-level stigma-reduction interventions in Zambia. Participant-level intervention: Women living with cervical cancer and HIV (WLC+H ) are randomized in a 2×2 factorial design of storytelling versus neutral videos and storytelling versus neutral disclosure interventions to assess effects on quality of life, anxiety, and depressive symptoms. Provider-level intervention: Healthcare workers are randomized to storytelling or neutral videos to assess changes in stigma and compassion. The study also evaluates participant -reported stigma and satisfaction with care before and after implementation of the provider intervention.

NCT Number	NCT07728370
Lead Sponsor	M.D. Anderson Cancer Center Collaborators: Cancer Diseases Hospital; University of Zambia
Conditions	HIV, Cervical Cancer Stigma
Enrollment	440 participants
Start Date	2026-09-01
Primary Completion	2030-05-31 (estimated)
Study Completion	2030-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-27