Clinical Trial

Study of Autologous, Metabolically Optimized, CD137+ Tumor-Infiltrating Lymphocytes Followed by Consolidative Oral Cyclophosphamide, Bevacizumab, and Pembrolizumab

Study acronym: OVAFIT-TIL
Not Yet Recruiting Phase 2
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Summary
Patients with recurrent ovarian cancer will undergo resection of a safely accessible metastatic lesion, from which tumor-infiltrating lymphocytes (TIL) will be cultured, metabolically reprogrammed for metabolic fit T cells, then selected for CD137+ activated T cells, and then expanded. This expanded TIL product will be infused following nonmyeloablative lymphodepletion chemotherapy. High-dose IL-2 will be given after TIL infusion to support the cell product expansion. Once recovered from TIL infusion, patients will start consolidative systemic therapy with oral cyclophosphamide, bevacizumab, and pembrolizumab.
Trial Details
NCT Number NCT07720180
Lead Sponsor Medical University of South Carolina
Conditions Ovarian Cancer
Enrollment 20 participants
Start Date 2026-12-01
Primary Completion 2031-12-01 (estimated)
Study Completion 2032-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-22