Metabolomics-Driven Insights Into Ultra-Processed Foods

The goal of this dietary intervention study in generally healthy adults is to develop new ways to use blood samples to measure the common types of highly processed foods and beverages that people eat on a regular basis. The main aims to answer are: What small molecules are elevated in blood after eating different types of highly processed foods and beverages consistently for 1 week? Researchers will compare 3 different test diets with 1 control diet that does not have any highly processed foods in the same individuals to see which circulating blood markers change. Participants will: * Complete 3 diet phases, each 2 weeks long * Receive a meal plan and study foods and beverages to follow for each 2-week phase * Come to the clinic every week for blood draws, urine samples, and stool collection kits

NCT Number	NCT07717970
Lead Sponsor	Brigham and Women's Hospital Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Broad Institute of MIT and Harvard
Conditions	Diet, Food and Nutrition
Enrollment	40 participants
Start Date	2027-01
Primary Completion	2028-03 (estimated)
Study Completion	2028-03 (estimated)
Updated on ClinicalTrials.gov	2026-07-21