Clinical Trial

Conversion Therapy With Retlirafusp Alfa Plus Chemotherapy in Gastric or Gastroesophageal Junction Adenocarcinoma

Not Yet Recruiting Phase 2
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Summary
This is a prospective, single-arm, exploratory clinical study designed to evaluate the efficacy and safety of retlirafusp alfa plus CAPOX as conversion therapy in patients with potentially resectable gastric or gastroesophageal junction adenocarcinoma. Eligible participants will receive preoperative retlirafusp alfa in combination with capecitabine and oxaliplatin. Patients who achieve complete response or partial response and are considered suitable for R0 resection after multidisciplinary team assessment will undergo radical surgery. The primary outcome is R0 resection rate.
Trial Details
NCT Number NCT07709767
Lead Sponsor Tang-Du Hospital
Conditions Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Enrollment 21 participants
Start Date 2026-08-30
Primary Completion 2028-12-30 (estimated)
Study Completion 2032-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-17