A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005)

Researchers are looking for new weight loss medicines for people with higher body weight. The trial medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a trial medicine to participants with a health condition, researchers first do trials in healthy participants to find a safe dose level (amount) of the trial medicine. The goal of this study is to learn what happens to MK-4082 in a person's body over time. Researchers will compare what happens to levels of MK-4082 in people's blood when it is taken alone (Part 1, Period 1 and Part 2) and in combination with (Part 1, Period 2) another medicine called diltiazem. Researchers also want to learn about the safety of MK-4082 taken with and without diltiazem and if people tolerate them.

NCT Number	NCT07697625
Lead Sponsor	Merck Sharp & Dohme LLC
Conditions	Healthy
Enrollment	28 participants
Start Date	2026-07-20
Primary Completion	2026-09-28 (estimated)
Study Completion	2026-09-28 (estimated)
Updated on ClinicalTrials.gov	2026-08-05