Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression

Previous work demonstrated that individuals are able to self-regulate their ventral tegmental area (VTA) activity using real-time biofeedback. The current study expands this approach to a larger sample with repeated training sessions to more robustly characterize the effects of VTA modulation. The study will assess change in mood and motivation-related measures, as well as neural activity and connectivity changes.

NCT Number	NCT07694076
Lead Sponsor	University of Oxford Collaborators: Wellcome Trust
Conditions	Major Depressive Disorder (MDD)
Enrollment	60 participants
Start Date	2026-06
Primary Completion	2031-06 (estimated)
Study Completion	2033-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-09