The Effects of Psilocybin on Social Connectedness

The study is a randomized, double-blind, placebo-controlled, expectancy-controlled, mechanistic trial. This study looks to explore whether a single dose of psilocybin (25mg) reduces amygdala reactivity to negative socioemotional stimuli during the Facial Emotion Recognition Task (FERT) compared to a placebo in adults who feel lonely or those with unresolved grief symptoms.

NCT Number	NCT07693153
Lead Sponsor	Yale University
Conditions	Loneliness, Grief
Enrollment	51 participants
Start Date	2026-08-31
Primary Completion	2031-12-15 (estimated)
Study Completion	2031-12-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-09