2026-09-02
notable
Study Identification, Study Status, Oversight, Arms and Interventions, Outcome Measures, Eligibility v1
Trial sites expanded: 0 → 7 locations
Primary completion pushed: 2028-02-02 → 2028-05-05
Completion pushed: 2029-03-29 → 2029-07-01
Start date2026-07-22→2026-10-23
Eligibility criteria+211 characters
[...] the participant's ability to eat
Receiving tube feedings or having an ongoing clinical indication for parenteral nutrition (either total or partial) at the time of screening or randomization.
Of note: short-term parenteral nutritional support for the management of acute, transient medical indications is allowed if discontinued prior to randomization.
Any prior or current clinical diagnosis of heart failure, ir [...]
Mixed small cell and non-small cell lung cancer histology.
Clinically significant ascites that requires medical intervention or underwent a paracentesis within 4 weeks prior to randomiz [...] [...]
Secondary endpoints5 entries, revised
ChangePercent change from baseline in 624-Minutehour Walkurinary Distancefree cortisol, morning serum cortisol, plasma ACTH, and nighttime salivary cortisol
Study title+5 characters
A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss