FIB-4 Cut-Offs for Liver Fibrosis in Obese Endocrinology Patients

This single-center, prospective observational study aims to assess the accuracy of FIB-4 cut-offs in identifying liver fibrosis in obese patients attending an endocrinology outpatient clinic in Italy. All consecutive eligible patients undergo routine blood tests and liver elastography (FibroScan) as part of clinical practice; FIB-4 values will be calculated and compared with liver stiffness measurements to evaluate the performance of FIB-4 thresholds for directing patients to FibroScan and hepatology care.

NCT Number	NCT07663188
Lead Sponsor	Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Conditions	MASLD
Enrollment	400 participants
Start Date	2026-09-01
Primary Completion	2027-09-01 (estimated)
Study Completion	2028-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-23