Breast-milk Enema Administration to Stimulate Passage of Meconium

Lack of passage of meconium in preterm infants delays feeding advancement and may represent a risk factor for necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP). Usual management of meconium impaction has included glycerin suppositories and normal saline enemas. Various methods are used in routine neonatal care to promote meconium evacuation; however, there is no consensus on the agents used and the frequency of applications

NCT Number	NCT07661992
Lead Sponsor	Wake Forest University Health Sciences
Conditions	Breast-milk
Enrollment	20 participants
Start Date	2026-10
Primary Completion	2027-03 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-28