Olfactory Dysfunction in Aging Adults

This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfactory testing, cognitive assessment, biomarker collection, and imaging to identify clinically relevant phenotypes based on anatomic site of dysfunction. The study will also evaluate the impact of olfactory dysfunction on quality of life and identify baseline factors associated with changes in olfactory function over time.

NCT Number	NCT07660887
Lead Sponsor	Medical University of South Carolina Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions	Olfactory Dysfunction
Enrollment	500 participants
Start Date	2027-04-01
Primary Completion	2032-04-30 (estimated)
Study Completion	2032-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-22