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Olfactory Transcranial Focused Ultrasound

Study acronym: O-tFUS
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Recruitment opened Study sites: 0 to 1 · Eligibility criteria expanded, about 9 words · Secondary endpoints: details revised at 1 of 3 entries · 1 more Show 4 more changesShow less
    • Study sites: 0 to 1
    • Eligibility criteria expanded, about 9 words
    • Secondary endpoints: details revised at 1 of 3 entries
    • Publications: details revised at 2 of 2 entries
  2. Start date: Sep 1, 2026 to Oct 1, 2026v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.
Trial Details
NCT Number NCT07658365
Lead Sponsor Medical University of South Carolina
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH)
Conditions Healthy, Olfaction
Enrollment 28 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov