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Perforated Appendicitis and Postoperative Antibiotics Pilot Trial

Study acronym: PAPA Pilot
StatusNot Yet Recruiting
PhaseNot applicable
Started2027-01-01
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Sep 1, 2027 → Jan 1, 2028
See other at-risk trials from London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Amendment history

2026-09-18
Primary completion pushed: 2027-09-01 → 2028-01-01
Completion pushed: 2027-11-01 → 2028-05-01
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix. This pilot study will also help determine whether a larger, multi-centre study can be successfully conducted. The main questions it aims to answer are: * Do patients who do not receive antibiotics after surgery have similar rates of infection after surgery as patients who do? * Is it feasible to enroll and randomize patients and collect complete health data for a larger multi-centre study? Researchers will compare patients who do not receive antibiotics after surgery to patients who do to see whether avoiding antibiotics is as effective as using antibiotics for preventing infections after surgery. Participants will: * Be randomly assigned to either receive or not receive antibiotics after surgery for their perforated (burst) appendix. * Be contacted 30 and 90 days after surgery to check for infections and other health outcomes.
Trial Details
NCT Number NCT07656636
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborators: Sunnybrook Health Sciences Centre
Conditions Perforated Appendicitis
Enrollment 100 participants
Start Date 2027-01-01
Primary Completion 2028-01-01 (estimated)
Study Completion 2028-05-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-17