Congenital Hemolytic and Dyserythropoietic Anemias

The main reason for this research study is to further understand how some red blood cells are formed incorrectly or they have an abnormal metabolism in a way that they break easier in the circulation or during their passage through the spleen. Participants and/or family members diagnosed with non-immune hemolytic anemia due to a genetic disorder, such as, hemoglobin disorder, erythrocyte membrane skeleton disorders (e.g. spherocytosis, elliptocytosis, or stomatocytosis) or hydration defect (e.g. xerocytosis, overhydrocytosis) or red blood cell (RBC) enzyme disorders, or with a congenital dyserythropoietic anemia (CDA) will be asked to participate.

NCT Number	NCT07649213
Lead Sponsor	Children's Hospital Medical Center, Cincinnati
Conditions	Hemolytic Anemia
Enrollment	400 participants
Start Date	2011-07-25
Primary Completion	2050-07 (estimated)
Study Completion	2052-07 (estimated)
Updated on ClinicalTrials.gov	2026-06-17