Furosemide vs Placebo in Severe Preeclampsia Postpartum

This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe preeclampsia. Secondary outcomes include need for rescue antihypertensive medications, weight reduction, and metabolic safety (hypokalemia, renal function). A total of 186 participants (93 per arm) will be enrolled across two hospitals in Honduras.

NCT Number	NCT07648251
Lead Sponsor	Universidad Nacional Autonoma de Honduras
Conditions	Severe Preeclampsia
Enrollment	186 participants
Start Date	2026-06-15
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-06-15