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Lattice Radiotherapy for Adults With Large Tumors

Study acronym: LRT
StatusNot Yet Recruiting
PhaseNot applicable
Started2027-01-01
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Nov 2029 → Apr 2030
See other at-risk trials from Duke University

Amendment history

2026-09-02
Study Status v2
Primary completion pushed: 2029-11 → 2030-04
Completion pushed: 2030-08 → 2031-01
Start date2026-08-01→2027-01-01
2026-06-29
Study Status, Outcome Measures, Eligibility v1
Primary endpoint(s) modified1 entry, revised
WasIncidence of Radiotherapy (RT) treatment-related, non-hematologic CTCAE v6.0 Grade ≥ 3 toxicity and Adverse Events of Special Interest (AESI) at 90 days
NowIncidence of Radiotherapy (RT) treatment-related, non-hematologic Common Terminology Criteria for Adverse Events (CTCAE) v6.0 Grade ≥ 3 toxicity and Adverse Events of Special Interest (AESI) at 90 days
Eligibility criteria+74 characters
[...] ve radiation treatment Life expectancy of at least 3 months Eastern Cooperative Oncology Group (ECOG) performance status ≤ 3 Patient must sign study-specific inf [...] . Receiving concurrent cytotoxic cancer therapy regimens or Vascular Endothelial Growth Factor (VEGF) inhibitor that would overlap with LRT administration. Cytot [...]
2026-06-10
Original filing
Duke University
455 trials monitored
See 53 trials at risk
The purpose of this study is to ask whether using a specialized radiation therapy technique called Lattice Radiation Therapy (LRT) can shrink large tumors when given with palliative radiation therapy. The primary questions are: * if LRT is safe and does not worsen existing side effects or cause new side effects * if adding LRT to standard radiation therapy can improve tumor shrinkage. Participants will have one additional radiation treatment (LRT) prior to starting palliative radiation and then their progress will be followed for one year.
Trial Details
NCT Number NCT07647679
Lead Sponsor Duke University
Conditions Large Tumor, Palliative Radiotherapy
Enrollment 25 participants
Start Date 2027-01-01
Primary Completion 2030-04 (estimated)
Study Completion 2031-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-08