Lattice Radiotherapy for Adults With Large Tumors

The purpose of this study is to ask whether using a specialized radiation therapy technique called Lattice Radiation Therapy (LRT) can shrink large tumors when given with palliative radiation therapy. The primary questions are: * if LRT is safe and does not worsen existing side effects or cause new side effects * if adding LRT to standard radiation therapy can improve tumor shrinkage. Participants will have one additional radiation treatment (LRT) prior to starting palliative radiation and then their progress will be followed for one year.

NCT Number	NCT07647679
Lead Sponsor	Duke University
Conditions	Large Tumor, Palliative Radiotherapy
Enrollment	25 participants
Start Date	2026-08-01
Primary Completion	2029-11 (estimated)
Study Completion	2030-08 (estimated)
Updated on ClinicalTrials.gov	2026-07-01