Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI

This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (\>60 min after admission in PCI-center) of PCI. Following randomisation a strategy of early tenecteplase and additional antiplatelet and antithrombin therapy followed by catheterisation within 2-24 hours with timely coronary intervention as appropriate (or by rescue coronary intervention if required) in Group A will be compared to primary PCI performed according to local standards in Group B.

NCT Number	NCT07641231
Lead Sponsor	National Medical Research Center for Cardiology, Ministry of Health of Russian Federation Collaborators: AO GENERIUM
Conditions	STEMI - ST Elevation Myocardial Infarction
Enrollment	240 participants
Start Date	2026-05-20
Primary Completion	2028-05-20 (estimated)
Study Completion	2029-05-20 (estimated)
Updated on ClinicalTrials.gov	2026-06-11