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NotableTrial status: Not Yet Recruiting to Recruiting
Start date: Oct 7, 2026 to Oct 8, 2026
MinorStart date: Oct 6, 2026 to Oct 7, 2026
MinorStart date: Oct 5, 2026 to Oct 6, 2026
MinorStart date: Oct 4, 2026 to Oct 5, 2026
MinorStart date: Sep 20, 2026 to Oct 4, 2026
Eligibility criteria expanded, about 11 words
MinorStart date: Sep 17, 2026 to Sep 20, 2026v66
MinorStart date: Sep 16, 2026 to Sep 17, 2026v65
MinorStart date: Sep 15, 2026 to Sep 16, 2026v64
MinorStart date: Sep 14, 2026 to Sep 15, 2026v63
MinorStart date: Sep 10, 2026 to Sep 14, 2026v62
MinorStart date: Sep 9, 2026 to Sep 10, 2026v61
MinorStart date: Sep 8, 2026 to Sep 9, 2026v60
MinorStart date: Sep 7, 2026 to Sep 8, 2026v59
MinorStart date: Sep 6, 2026 to Sep 7, 2026v58
MinorStart date: Sep 3, 2026 to Sep 6, 2026v57
MinorStart date: Sep 2, 2026 to Sep 3, 2026v56
MinorStart date: Sep 1, 2026 to Sep 2, 2026v55
MinorStart date: Aug 31, 2026 to Sep 1, 2026v54
MinorStart date: Aug 30, 2026 to Aug 31, 2026v53
MinorStart date: Aug 27, 2026 to Aug 30, 2026v52
MinorStart date: Aug 26, 2026 to Aug 27, 2026v51
MinorStart date: Aug 25, 2026 to Aug 26, 2026v50
MinorStart date: Aug 24, 2026 to Aug 25, 2026v49
MinorStart date: Aug 23, 2026 to Aug 24, 2026v48
MinorStart date: Aug 20, 2026 to Aug 23, 2026v47
MinorStart date: Aug 19, 2026 to Aug 20, 2026v46
MinorStart date: Aug 18, 2026 to Aug 19, 2026v45
MinorStart date: Aug 17, 2026 to Aug 18, 2026v44
MinorStart date: Aug 16, 2026 to Aug 17, 2026v43
MinorStart date: Aug 13, 2026 to Aug 16, 2026v42
MinorStart date: Aug 12, 2026 to Aug 13, 2026v41
MinorStart date: Aug 11, 2026 to Aug 12, 2026v40
MinorStart date: Aug 10, 2026 to Aug 11, 2026v39
MinorStart date: Aug 7, 2026 to Aug 10, 2026v38
MinorStart date: Aug 6, 2026 to Aug 7, 2026v37
MinorStart date: Aug 5, 2026 to Aug 6, 2026v36
MinorEnrollment increased: 300 → 410 participants
Start date: Aug 4, 2026 to Aug 5, 2026
v35
MinorStart date: Aug 3, 2026 to Aug 4, 2026v34
MinorEnrollment target: 300 to 410
Start date: Aug 2, 2026 to Aug 3, 2026
v33
MinorStart date: Jul 30, 2026 to Aug 2, 2026v32
MinorStart date: Jul 29, 2026 to Jul 30, 2026v31
MinorStart date: Jul 28, 2026 to Jul 29, 2026v30
MinorStart date: Jul 27, 2026 to Jul 28, 2026v29
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need mental health care. Yet no therapies have been developed just to target irritability. Researchers want to compare different types of therapy for irritability.
Objective:
To test different types of therapy for children and teens with severe irritability.
Eligibility:
People aged 8 to 16.5 years with severe irritability. Their parents are also needed.
Design:
Participants will have 28 study visits in 18 months.
They will have a baseline visit. They will answer questions about their mood, behavior, and daily life.
All parents and children will have 12 therapy sessions. Sessions will be once a week; they will last 30 to 60 minutes. Some of the child sessions may be done by telehealth.
Each parent and child will have 1 of 3 therapy types:
Exposure therapy (child). Participants will face things that make them angry. A therapist will help them practice managing their anger.
Management therapy (parent). Therapists will coach parents on ways to manage their child s behaviors.
Psychoeducation/supportive psychotherapy (child and/or parent). Participants will talk with therapists about their or their child s feelings and behaviors. They will list their problems and goals; build coping skills; learn to relax; improve communication; and work on managing stress.
Sessions may be videotaped. Participants may opt out of being recorded.
Participants will have phone calls every 2 weeks during therapy. They will answer questions about how they are doing. Follow-up calls will continue for 1 year after therapy.