Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress: the Lift RCT

Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress. These problems that are hard to treat because access to mental health care is often limited. To help address this, the researchers created Lift, a fully automated mindfulness program designed with patient input and delivered through a mobile app. The investigators now plan a large, multi-site study to test whether Lift improves mental health and quality of life over six months compared to a critical illness education program called Enlighten Recovery. Overall the goal is to make an easy-to-use, widely accessible program available to people across the U.S., including those who speak Spanish.

NCT Number	NCT07634419
Lead Sponsor	Duke University Collaborators: National Institutes of Health (NIH), National Center for Complementary and Integrative Health (NCCIH)
Conditions	Critical Illness, Heart Failure, Sepsis, Ards, Pneumonia, Trauma Injury
Enrollment	450 participants
Start Date	2026-06-01
Primary Completion	2031-02-28 (estimated)
Study Completion	2031-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-10