Clinical Trial

Surgery vs. Radical Chemoradiotherapy for Esophageal SCC After Neoadjuvant Immunochemotherapy

Study acronym: HCHTOG2603
Not Yet Recruiting Phase 3
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Summary
This is a Phase III, multicenter, open-label, randomized controlled trial. The study aims to compare organ preservation versus esophagectomy in patients with locally advanced, resectable thoracic esophageal squamous cell carcinoma (ESCC) who achieve a complete or partial clinical response (cCR/cPR) following neoadjuvant immunochemotherapy.
Trial Details
NCT Number NCT07629817
Lead Sponsor Henan Cancer Hospital
Conditions Esophageal Squamous Cell Carcinoma
Enrollment 1,044 participants
Start Date 2026-06-15
Primary Completion 2032-03-15 (estimated)
Study Completion 2032-03-15 (estimated)
Updated on ClinicalTrials.gov 2026-06-10