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Surgery vs. Radical Chemoradiotherapy for Esophageal SCC After Neoadjuvant Immunochemotherapy

Study acronym: HCHTOG2603
StatusRecruiting
PhasePhase 3
Started2026-06-16
View on ClinicalTrials.gov ↗

Amendment history

2026-07-30
Study Status, Eligibility, Contacts/Locations v2
Recruitment opened
Start dateestimated 2026-06-15→confirmed 2026-06-16
Study sites0→1
Eligibility criteria-194 characters
Inclusion Criteria: - Based on the study protocol, the Inclusion Criteria translated into English are as follows: Age 18-75 years, any sex. ECOG Performance Status 0-1. Histo [...] ed written informed consent form (ICF). Exclusion Criteria: - Based on the study protocol, the Exclusion Criteria you listed translate into English as follows: History of other malignancy within the past 5 years. Active [...]
2026-06-07
Study Identification, Study Status v1
Study title-175 characters
A Multicenter, Open-Label, Randomized Controlled Phase III Clinical Trial Comparing Surgery Versusvs. Radical Chemoradiotherapy (Organ Preservation) in Patients With Thoracicfor Esophageal SquamousSCC Cell Carcinoma Achieving cCR or cPR FollowingAfter Neoadjuvant Immunochemotherapy
2026-06-01
Original filing
This is a Phase III, multicenter, open-label, randomized controlled trial. The study aims to compare organ preservation versus esophagectomy in patients with locally advanced, resectable thoracic esophageal squamous cell carcinoma (ESCC) who achieve a complete or partial clinical response (cCR/cPR) following neoadjuvant immunochemotherapy.
Trial Details
NCT Number NCT07629817
Lead Sponsor Henan Cancer Hospital
Conditions Esophageal Squamous Cell Carcinoma
Enrollment 1,044 participants
Start Date 2026-06-16
Primary Completion 2032-03-15 (estimated)
Study Completion 2032-03-15 (estimated)
Updated on ClinicalTrials.gov 2026-07-31