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GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

StatusRecruiting
PhaseEarly Phase 1
Started
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Record History

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  1. Recruitment opened Show 6 more changesShow less
    • Start date: Jul 10, 2026 to Oct 10, 2026
    • Primary endpoints: details revised at 1 of 1 entry
    • Eligibility criteria expanded, about 85 words
    • Secondary endpoints: details revised at 2 of 3 entries
    • Study description revised
    • Site details revised
  2. Start date: Jun 30, 2026 to Jul 10, 2026
    • Eligibility criteria expanded, about 20 words
    v4
  3. Re-verified, no change to tracked fieldsv3
  4. Eligibility criteria shortened, about 68 wordsv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
There is a growing number of patients diagnosed with gastrointestinal cancers who are also simultaneously being treated with GLP-1 Receptor Agonists (RA)s. To date, no clinical trial data exists to establish safety and/or feasibility with use of GLP-1 RAs during chemotherapy in the metastatic setting. The goal of this clinical trial is to evaluate the safety, tolerability, preliminary efficacy, and correlative analyses of combining GLP-1 RAs with standard chemotherapy in patients with metastatic pancreatic, colorectal, or hepatocellular cancers in the first-line setting.
Trial Details
NCT Number NCT07627191
Lead Sponsor University of Arizona
Conditions
(from sponsor)		 Pancreatic Cancer, Colorectal Cancer, Hepatocellular Carcinoma
Related terms Carcinoma, Hepatocellular, Colorectal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov