Clinical Trial

Sevoflurane vs Propofol Anesthesia in Obese Patients Undergoing Lumbar Surgery

Recruiting
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Record status
This record was last updated May 28, 2026 (before its estimated June 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
This randomized, single-center, single-masked clinical trial aims to compare the immunomodulatory effects of sevoflurane-based inhalational anesthesia and propofol-based total intravenous anesthesia in obese patients undergoing elective lumbar instrumentation surgery. Seventy patients will be randomized into two groups: a propofol group and a sevoflurane group. Blood samples will be collected preoperatively, at postoperative 6 hours, and at postoperative 24 hours. Pentraxin-3 and serum amyloid A levels will be evaluated as primary inflammatory biomarkers together with IL-6, TNF-α, CRP, glucose, and complete blood count parameters.
Trial Details
NCT Number NCT07611240
Lead Sponsor Ataturk University
Conditions Obesity & Overweight, Lumbar Spine Surgery
Enrollment 70 participants
Start Date 2025-06-15
Primary Completion 2026-06-15 (estimated)
Study Completion 2026-06-16 (estimated)
Updated on ClinicalTrials.gov 2026-05-28