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Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)

Study acronym: POPLIN
StatusRecruiting
PhasePhase 4
Started2026-07-15
View on ClinicalTrials.gov ↗

Amendment history

2026-09-10
minor
Study Status, Contacts/Locations v3
Study sites3→4
2026-08-19
minor
Study Status, Contacts/Locations v2
Study sites2→3
2026-07-28
notable
Study Status, Contacts/Locations v1
Recruitment opened
Start dateestimated 2026-07-17→confirmed 2026-07-15
Study sites0→2
2026-05-20
minor
Original filing
148 trials monitored
See 16 trials at risk
1,228 trials monitored
See 75 trials at risk
This study is researching whether the use of tocilizumab before the first dose of linvoseltamab will decrease the risk of Cytokine Release Syndrome (CRS) in participants who have Relapsed or Refractory Multiple Myeloma (RRMM) who have already been treated with at least four lines of treatment for their multiple myeloma, including medicines called a proteasome inhibitor, an immunomodulatory drug, and an anti-Cluster of Differentiation (CD) 38 antibody. The aim of the study is to see how safe, tolerable and effective linvoseltamab is when given after tocilizumab. The study is looking at several other research questions, including: * What side effects may happen from taking tocilizumab before the first dose of linvoseltamab * Whether tocilizumab has an impact on CRS, including whether participants require hospital care and, if so, how many hospital visits occur and how long they last * How frequently other medications (for example, corticosteroids or additional doses of tocilizumab) are used to support participants' care if needed
Trial Details
NCT Number NCT07609940
Lead Sponsor Regeneron Pharmaceuticals
Conditions Relapsed/Refractory Multiple Myeloma (RRMM)
Enrollment 30 participants
Start Date 2026-07-15
Primary Completion 2027-10-11 (estimated)
Study Completion 2028-12-06 (estimated)
Updated on ClinicalTrials.gov 2026-09-25