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Accelerated iTBS for Major Depression

Name: Accelerated iTBS for Major Depression — clinical trial record (NCT07603804)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: AIM-D

StatusRecruiting

PhaseNot applicable

SponsorIstanbul University - Cerrahpasa

Started2026-03-08

View on ClinicalTrials.gov ↗

Istanbul University - Cerrahpasa

276 trials monitored

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Depression

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Major depressive disorder (MDD) is a common and disabling psychiatric condition, and many patients do not achieve adequate response to standard antidepressant treatments. Accelerated intermittent theta burst stimulation (iTBS) is a promising neuromodulation approach that may provide rapid antidepressant effects. This prospective interventional study aims to evaluate the clinical effectiveness of accelerated bilateral dorsomedial prefrontal cortex iTBS in patients with MDD and to investigate treatment-related changes in neurobiological biomarkers, including cortisol, ACTH, BDNF, IL-1β, IL-6, TNF-α, and CRP. Associations between biomarker changes and treatment response will also be examined.

Trial Details

NCT Number	NCT07603804
Lead Sponsor	Istanbul University - Cerrahpasa
Conditions	Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Enrollment	35 participants
Start Date	2026-03-08
Primary Completion	2026-12 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-22