Clinical Trial

Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)

Study acronym: ARTMA
Not Yet Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
In this single center, interventional pilot study, 40 participants at high risk for future exacerbation will be randomized to anakinra (v. placebo control) treatment for home administration as part of an asthma action plan (AAP) and monitored through their first moderate asthma exacerbation, triggering treatment dosing over a 26 week period. Key feasibility questions will be assessed in this pilot study to inform trial design and sample size selection for a future multi-site phase II clinical trial testing anakinra as a rescue treatment for moderate asthma exacerbations.
Protocol Amendment History 3 changes
critical Primary endpoint(s) modified 2026-07-16
notable Primary completion pushed: 2028-12-01 -> 2029-01-01 2026-07-16
minor Completion pushed: 2028-12-01 -> 2029-01-01 2026-07-16
Trial Details
NCT Number NCT07600190
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions Asthma (Diagnosis), Persistent Asthma, Moderate Asthma Exacerbation
Enrollment 60 participants
Start Date 2026-11-01
Primary Completion 2029-01-01 (estimated)
Study Completion 2029-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-15