Clinical Trial

Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy

Name: Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy — clinical trial record (NCT07600177)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: CMI-SWITCH

Recruiting Phase 4

View on ClinicalTrials.gov →

Summary

This is an investigator-initiated two-center study. The goal of this study is to investigate the feasibility, safety and efficacy outcomes of a seamless transition from mavacamten to aficamten in patients with obstructive hypertrophic cardiomyopathy (oHCM).

Trial Details

NCT Number	NCT07600177
Lead Sponsor	Oregon Health and Science University Collaborators: Saint Lukes Hospital Mid America Heart Institute, Cytokinetics
Conditions	Hypertrophic Cardiomyopathy (HCM)
Enrollment	40 participants
Start Date	2026-05-05
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-20