A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

NCT Number	NCT07595549
Lead Sponsor	Pfizer
Conditions	Obesity, Overweight and/or Obesity, Overweight
Enrollment	954 participants
Start Date	2026-06-10
Primary Completion	2028-05-04 (estimated)
Study Completion	2028-06-21 (estimated)
Updated on ClinicalTrials.gov	2026-07-22