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The Effect Of Lisinopril On Polycythemia

Name: The Effect Of Lisinopril On Polycythemia — clinical trial record (NCT07594535)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 4

SponsorMayo Clinic

Started2026-07-01

View on ClinicalTrials.gov ↗

Amendment history

2026-08-19

Study Status, Contacts/Locations v1

Recruitment opened

Study sites1→2

2026-05-13

Original filing

Mayo Clinic

1,015 trials monitored

See 115 trials at risk

The purpose of this study is to evaluate the effect of the (angiotensin-converting enzyme) ACE inhibitor lisinopril on hemoglobin, hematocrit, and erythropoietin levels in patients with secondary polycythemia due to high-oxygen-affinity hemoglobin variants, oxygen-sensing pathway mutations, or other unexplained and potentially irreversible forms of erythrocytosis. This study aims to determine whether ACE inhibition can effectively reduce excessive erythrocytosis by modulating erythropoietin production.

Trial Details

NCT Number	NCT07594535
Lead Sponsor	Mayo Clinic
Conditions	Polycythemia
Enrollment	30 participants
Start Date	2026-07-01
Primary Completion	2028-07-01 (estimated)
Study Completion	2029-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-21