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Perioperative Vericiguat in Patients Undergoing Cardiovascular Surgery

StatusNot Yet Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
The purpose of this study is to evaluate the efficacy and safety of perioperative vericiguat in patients undergoing cardiovascular surgery. Patients at high risk of heart failure or with confirmed cardiac dysfunction will be randomly assigned to receive either vericiguat plus standard of care or standard of care alone. The primary objective is to determine whether perioperative administration of vericiguat can reduce (I) the Incidence of Early Postoperative Hemodynamic Deterioration or Clinically Significant Myocardial Injury; (II) Incidence of Major Sterile Inflammation-Related Organ Injuries (MSIRI), and the incidence of Major Adverse Cardiovascular Events (MACE) within 12 months after surgery.
Trial Details
NCT Number NCT07594509
Lead Sponsor Nanjing Medical University
Collaborators: Beijing Anzhen Hospital, The Affiliated Hospital of Qingdao University, Changzhou First People's Hospital, The First Affiliated Hospital of Guangzhou Medical University, The First Affiliated Hospital of Bengbu Medical University, West China Hospital, Shanghai East Hospital, China
Conditions
(from sponsor)		 Cardio Vascular Disease, Cardiopulmonary Bypass
Enrollment 600 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov