Molecular Profiling for Risk Stratification in Appendiceal Cancer

This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.

NCT Number	NCT07587268
Lead Sponsor	City of Hope Medical Center
Conditions	Appendiceal Cancer, Appendiceal Adenocarcinoma
Enrollment	400 participants
Start Date	2026-05-01
Primary Completion	2027-01-01 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-29