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Effect of Finerenone on Myocardial Fibrosis and Cardiac Function in HFmrEF/HFpEF Patients

Name: Effect of Finerenone on Myocardial Fibrosis and Cardiac Function in HFmrEF/HFpEF Patients — clinical trial record (NCT07583173)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: FINE-FOCUS

StatusNot Yet Recruiting

PhasePhase 4

SponsorChina National Center for Cardiovascular Diseases

Started2026-05-15

View on ClinicalTrials.gov ↗

China National Center for Cardiovascular Diseases

127 trials monitored

See 4 trials at risk

Heart Failure

1,854 trials monitored

See 95 trials at risk

FINE-FOCUS study is a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of Finerenone versus placebo on myocardial fibrosis and cardiac structure/function as assessed by cardiac magnetic resonance (CMR) in symptomatic heart failure patients with a left ventricular ejection fraction (LVEF) ≥40%. A sub-study will include 18F-FAPI-PET/CT imaging to evaluate the effect of finerenone on myocardial fibrosis.

Trial Details

NCT Number	NCT07583173
Lead Sponsor	China National Center for Cardiovascular Diseases
Conditions	Heart Failure
Enrollment	104 participants
Start Date	2026-05-15
Primary Completion	2027-10-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-13