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A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis

Study acronym: DUET ENCORE-UC
StatusRecruiting
PhasePhase 3
Started2026-05-23
View on ClinicalTrials.gov ↗
The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants with moderately to severely active ulcerative colitis (UC, a chronic disease of the large intestine in which the lining of the colon becomes inflamed and develops ulcers).

Amendment history 5 changes detected by DataLookout

2026-08-29
Trial sites expanded: 63 → 170 locations
2026-08-01
Trial sites expanded: 26 → 63 locations
2026-07-07
Trial sites expanded: 6 → 26 locations
2026-06-09
Recruitment opened
2026-06-09
Trial sites expanded: 0 → 6 locations
Trial Details
NCT Number NCT07577856
Lead Sponsor Janssen Research & Development, LLC
Conditions Colitis, Ulcerative
Enrollment 644 participants
Start Date 2026-05-23
Primary Completion 2028-08-11 (estimated)
Study Completion 2030-10-16 (estimated)
Updated on ClinicalTrials.gov 2026-08-28