Study to Understand Relationship Between Gut Health and Toxicities of Hormonal Breast Cancer Treatment

This study will be conducted in 2 sequential parts. The first part will be a prospective, observational study. This will be followed by a small interventional, pilot study involving use of fiber supplement (chia seeds). The study aims to evaluate the relationship between the gut microbiome (a diverse ecosystem of microorganisms that affects your health and well-being) and treatment-related gastrointestinal toxicities in patients with HR+/HER2- breast cancer receiving abemaciclib plus endocrine therapy.

NCT Number	NCT07553234
Lead Sponsor	University of Chicago
Conditions	Breast Cancer
Enrollment	20 participants
Start Date	2026-12-27
Primary Completion	2030-05-03 (estimated)
Study Completion	2030-05-03 (estimated)
Updated on ClinicalTrials.gov	2026-05-04