Clinical Trial

Dual-target CD70/CAIX CAR-NK Cells for Advanced Clear Cell Renal Cell Carcinoma

Study acronym: DUAL-NK RCC
Recruiting Phase 1/2
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Summary
Phase 1/2 study evaluates the safety, feasibility, and preliminary antitumor activity of allogeneic dual-target CD70/CAIX CAR-NK cells after fludarabine/cyclophosphamide lymphodepletion in adults with advanced or metastatic clear cell RCC that has progressed after standard therapy. The study is designed to determine a recommended dose and schedule, characterize hepatobiliary safety, and explore whether CD70-high, CAIX-high, or dual-high tumors derive the greatest benefit. Biomarker-defined activity signals will be used to guide whether later development should prioritize CD70, CAIX/CA9, or continued dual-targeting.
Trial Details
NCT Number NCT07551349
Lead Sponsor Beijing Biotech
Conditions Advanced or Metastatic Clear Cell Renal Cell Carcinoma
Enrollment 36 participants
Start Date 2026-02-02
Primary Completion 2027-04-14 (estimated)
Study Completion 2028-04-17 (estimated)
Updated on ClinicalTrials.gov 2026-04-24