Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE)

The goal of this clinical trial is to find out whether changing the microbes in the bowels of Veterans with cirrhosis and hepatic encephalopathy (a condition that affects the brain as a result of liver problems) using capsules made from microbes from healthy people can prevent future episodes of hepatic encephalopathy.

NCT Number	NCT07528690
Lead Sponsor	VA Office of Research and Development
Conditions	Hepatic Encephalopathy, Cirrhosis
Enrollment	162 participants
Start Date	2026-10-30
Primary Completion	2030-10-31 (estimated)
Study Completion	2031-03-03 (estimated)
Updated on ClinicalTrials.gov	2026-04-14