Clinical Trial

A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

Active, Not Recruiting Phase 1
View on ClinicalTrials.gov →
Record status
This record was last updated August 3, 2026 (before its estimated August 10, 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this study is to learn about the effect of a study medicine called MK-8527 when taken with methadone. The study will also measure what happens to the methadone in a healthy person's body over time after MK-8527 is taken.
Protocol Amendment History 2 changes
critical Enrollment closed, study ongoing 2026-08-04
critical Recruitment opened 2026-06-03
Trial Details
NCT Number NCT07528508
Lead Sponsor Merck Sharp & Dohme LLC
Conditions Healthy
Enrollment 14 participants
Start Date 2026-05-22
Primary Completion 2026-08-10 (estimated)
Study Completion 2026-08-10 (estimated)
Updated on ClinicalTrials.gov 2026-08-03