Pain & Reward Neuromodulation of CNS Circuits

This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.

NCT Number	NCT07525063
Lead Sponsor	Duke University Collaborators: American Fibromyalgia Syndrome Association
Conditions	Fibromyalgia Syndrome, Fibromyalgia, Chronic Pain and Fatigue
Enrollment	30 participants
Start Date	2026-07-21
Primary Completion	2026-12 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-28