Clinical Trial

Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration

Study acronym: CLEAR
Recruiting
View on ClinicalTrials.gov →
Summary
The objective of this clinical investigation is to evaluate the feasibility, safety, and effectiveness of a concomitant procedure involving the Volt PFA System and Amulet 2 device in patients indicated for both AF ablation and percutaneous LAAO.
Protocol Amendment History 8 changes
notable Trial sites expanded: 13 -> 16 locations 2026-07-14
critical Trial status changed: Withheld → Recruiting 2026-05-28
critical Phase changed: not specified -> not applicable 2026-05-28
critical Primary endpoint(s) modified 2026-05-28
notable Enrollment changed: None -> 240 2026-05-28
notable Sponsor changed: [Redacted] -> Abbott Medical Devices 2026-05-28
minor Trial arms changed: 0 -> 1 2026-05-28
notable Trial sites expanded: 0 -> 13 locations 2026-05-28
Trial Details
NCT Number NCT07523620
Lead Sponsor Abbott Medical Devices
Conditions Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation
Enrollment 240 participants
Start Date 2026-03-31
Primary Completion 2027-05-31 (estimated)
Study Completion 2028-02-28 (estimated)
Updated on ClinicalTrials.gov 2026-07-13