Mapping LIFU Responses Using iEEG Recordings

The current study presents a unique opportunity to measure the immediate neural responses to brief, non-therapeutic transcranial low-intensity focused ultrasound (LIFU) pulses using intracranial electrodes. By recording time-locked signals in local and distant brain regions we can characterize circuit connectivity in real-time. We will use adult patients undergoing intracranial electrophysiological monitoring in an inpatient setting as our targeted population.

NCT Number	NCT07518927
Lead Sponsor	University of Pennsylvania
Conditions	Low Intensity Focussed Ultrasound, Electrodes, Implanted
Enrollment	30 participants
Start Date	2026-03-04
Primary Completion	2031-03-04 (estimated)
Study Completion	2031-03-04 (estimated)
Updated on ClinicalTrials.gov	2026-04-09