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Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

Study acronym: KARDINAL-ASH
StatusRecruiting
PhasePhase 2
Started
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Record History

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  1. Site details revised at 1 of 13 sites
  2. Study sites: 11 to 13
    • Eligibility criteria expanded, about 11 words
    • Secondary endpoints: details revised at 3 of 8 entries
    • Study description expanded, about 5 words
  3. Trial sites expanded: 8 → 11 locationsv4
  4. Primary endpoint(s) modifiedv3 Show 9 more changesShow less
    • Enrollment increased: 100 → 140 participants
    • Trial sites expanded: 4 → 8 locations
    • Primary completion date: Dec 29, 2026 to Dec 2026
    • Study completion date: Feb 23, 2027 to Feb 2027
    • Start date changed from estimate of Apr 20, 2026 to Jun 23, 2026
    • Eligibility criteria expanded, about 28 words
    • Secondary endpoints: 2 to 8
    • Study description revised
    • Study title expanded, about 3 words
  5. Recruitment opened
    • Trial sites expanded: 1 → 4 locations
    v2
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
Trial Details
NCT Number NCT07511361
Lead Sponsor Kardigan, Inc.
Conditions
(from sponsor)		 Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency
Related terms Hypertension, Hypertensive Crisis
Enrollment 140 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov