Clinical Trial

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

Study acronym: KARDINAL-ASH
Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
Protocol Amendment History 5 changes
critical Primary endpoint(s) modified 2026-07-02
notable Enrollment increased: 100 -> 140 participants 2026-07-02
notable Trial sites expanded: 4 -> 8 locations 2026-07-02
critical Recruitment opened 2026-05-07
notable Trial sites expanded: 1 -> 4 locations 2026-05-07
Trial Details
NCT Number NCT07511361
Lead Sponsor Kardigan, Inc.
Conditions Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency
Enrollment 140 participants
Start Date 2026-06-23
Primary Completion 2026-12 (estimated)
Study Completion 2027-02 (estimated)
Updated on ClinicalTrials.gov 2026-07-01