Clinical Trial

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Study acronym: AMAZE 6
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Protocol Amendment History 3 changes
critical Recruitment opened 2026-05-16
notable Trial sites expanded: 78 -> 81 locations 2026-05-16
notable Primary completion pushed: 2028-06-19 -> 2028-08-14 2026-05-16
Trial Details
NCT Number NCT07509307
Lead Sponsor Novo Nordisk A/S
Conditions Obesity, Overweight, Osteoarthritis, Knee
Enrollment 400 participants
Start Date 2026-04-20
Primary Completion 2028-08-14 (estimated)
Study Completion 2028-08-14 (estimated)
Updated on ClinicalTrials.gov 2026-07-09