CARED : A Novel Rapid Treatment Paradigm for Depression

The purpose of this study is to primarily assess the feasibility and secondarily assess the efficacy of a single session intervention (SSI) that combines non-invasive brain stimulation and psychotherapy for Major Depressive Disorder (MDD). investigators will recruit 30 people with MDD, with at least mild to moderate symptoms, who are resistant to typical treatments for Major Depressive Disorder. In this trial, participants will receive psychotherapy, Intermittent Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS), and either active or sham (placebo) Transcranial Alternating Current Stimulation (tACS).

NCT Number	NCT07507370
Lead Sponsor	University of North Carolina, Chapel Hill Collaborators: Foundation of Hope, North Carolina
Conditions	Major Depressive Disorder
Enrollment	30 participants
Start Date	2026-04-14
Primary Completion	2028-07-01 (estimated)
Study Completion	2028-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-25