Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury

The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury. The main questions it aims to answer are: * Can site specific spinal cord stimulation enhance blood pressure regulation? * Does this stimulation affect enzymes responsible for blood pressure regulation? Researchers will stimulate different sites of spinal cord and compare to see if site-specific stimulation provide blood pressure stability. Participants will have up to six pairs of self-adhesive conductive electrodes placed on the skin over the spinal cord (midline and/or just to the left and right of midline) as cathodes and up to six pairs of self-adhesive electrodes located symmetrically on the skin over the iliac crests, clavicles, shoulders, and/or abdominal muscles (left and right of the umbilicus) as anodes for stimulation of the spinal cord.

NCT Number	NCT07504055
Lead Sponsor	University of Louisville Collaborators: Kentucky Spinal Cord and Head Injury Research Board
Conditions	Spinal Cord Injury, Orthostatic Hypertension, Autonomic Dysreflexia
Enrollment	40 participants
Start Date	2026-04-01
Primary Completion	2029-02 (estimated)
Study Completion	2029-02 (estimated)
Updated on ClinicalTrials.gov	2026-04-28